Upregulation of PD-1 expression on HIV-specific CD[8.sup.+] T cells leads to reversible immune dysfunction
Article Abstract:
A study was conducted to show that programmed death 1 (PD-1) was upregulated on HIV-specific CD[8.sup.+] T cells and PD-1 expression levels were significantly correlated both with viral load and with the reduced capacity for cytokine production and proliferation of HIV-specific CD[8.sup.+] T cells. The results suggest that PD-1 HIV-specific CD[8.sup.+] T cell could persist throughout the course of infection which could be advantageous for the virus, because it hampers the renewal of functional virus-specific CD[8.sup.+] T cells by accumulating a functionally impaired population and preventing the re-establishment of a niche of functionally competent T cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Taking the brake off T cells in chronic viral infection
Article Abstract:
CD8(super +) T cells lose much of their ability to proliferate, produce cytokines and kill during chronic viral infections. Therapy with PD-L1, one of the ligands for programmed cell death 1 (PD-1), specific antibody restored impaired CD8+ T-cell functions in lymphocytic choriomeningitis virus infection and thus it shows that this mechanism operates in a model of chronic viral infection and that it can be a therapeutic target to revert T-cell dysfunction.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Altered recognition of antigen is a mechanism of CD8+T cell tolerance in cancer
Article Abstract:
The study looked at the behaviour of T-cells tolerance in cancer, and recorded previously unknown findings.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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